Sildenafil Citrate/Duloxetine

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PackageDosagePricePrice per Dose
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Dosage: 100/60mg
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Sildenafil Citrate/Duloxetine Description

Overview and indications

Sildenafil Citrate/Duloxetine is a combination medicine offered by some online pharmacies. It pairs a PDE5 inhibitor with an SNRI antidepressant to address two concerns that can occur together in adults: erectile dysfunction and mood or pain symptoms. Availability and approvals vary by country, and a clinician must authorize use. For customers, it is marketed as a convenient, single-prescription option, but it requires careful medical supervision to balance benefits and risks.

How it works

Sildenafil relaxes the smooth muscles in the penis and increases blood flow when arousal occurs. Duloxetine raises serotonin and norepinephrine levels in the brain, helping mood and some types of pain. Together, the drugs may improve sexual function while addressing anxiety or chronic pain. Because they work in different body systems, this combo can help a subset of patients, but it adds interactions and side effects to monitor.

Dosage and administration

Your clinician sets the dose based on health, symptoms, and other medicines. A typical sildenafil dose for on-demand use is 25 to 100 mg, not more than once daily. Duloxetine is usually taken daily at 30 to 60 mg, with possible adjustments. In a fixed combination, amounts are tailored to the person’s needs. Always follow the clinician’s instructions and the pharmacy label.

Take sildenafil about 30 to 60 minutes before activity; fat meals can slow onset. Duloxetine should be swallowed with water, with or without meals. Avoid alcohol, which can worsen dizziness and blood pressure changes. Do not change the dose on your own, and report any signs of adverse effects promptly.

What to expect and effectiveness

People may notice firmer erections within the first hour after taking sildenafil, assuming arousal is present. Duloxetine benefits for mood or pain often take several weeks. Some users report reduced performance anxiety and less pain during intercourse. A fair trial of several weeks helps decide if the combination meets personal goals. If not, discuss alternatives with a clinician.

Safety, side effects, and interactions

Common side effects include headache, flushing, dizziness, and stomach upset. Duloxetine can cause nausea, dry mouth, sleep changes, and sweating. Sildenafil may cause nasal congestion or lightheadedness. Serious risks include a prolonged erection and interactions with nitrates or other serotonergic drugs. Always tell your doctor about all medicines and supplements. This combo is not suitable for everyone, especially those with heart disease, kidney or liver problems, or uncontrolled blood pressure.

Who should consider it and practical notes

This combination is for adults with erectile dysfunction and concurrent mood or pain symptoms that respond to duloxetine and sildenafil. It is not suitable for pregnancy or minors. People taking nitrates, certain blood pressure meds, or other antidepressants need careful monitoring. Always obtain medicines from a reputable source, store safely, and follow up with a clinician to review symptoms and side effects.